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Bifidobacterium improves oestrogen-deficiencyinduced osteoporosis in mice by modulating intestinal immunity（1）

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Health Benefits

This research paper explores how Bifidobacterium This research paper explores how Bifidobacterium bifidum (Bifidobacterium) improves oestrogen-deficiency-induced osteoporosis in mice by modulating intestinal immunity. The researchers used two Bifidobacterium strains (B. bifidum FL228.1 and B. animalis subsp. Lactis F1-7), both of which have been shown to reduce intestinal inflammation.

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    Study Background

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    * Osteoporosis is a major health problem in the middle-aged and elderly population and the number of people affected by osteoporosis is increasing as the population ages.
    * Gut flora is closely related to the human immune system, and an overactive immune system is closely related to bone resorption.
    * Probiotics can effectively improve bone density and strength, reduce bone loss, and improve osteoporosis, but their mechanism of action and relationship with gut flora are not clear.

    Research Methods

    * The researchers selected two Bifidobacterium strains (B. bifidum FL228.1 and B. animalis subsp. Lactis F1-7) with intestinal inflammation-relieving effects.

    * To test the ameliorative effects of Bifidobacteria on osteoporosis and to explore the effects of Bifidobacteria on intestinal immunity by constructing a de-ovulated mouse model.

    * The researchers analysed the effects of probiotics on gut barrier, intestinal inflammation and gut flora structure in de-ovulated mice and explored their mechanisms of action.

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    Research findings

    * Bifidobacterium bifidum can improve osteoporosis: It was found that both strains of bacteria could significantly increase bone mineral density, bone volume/total volume ratio, and trabecular number in de-ovulated mice, and effectively inhibit bone loss.

    * Bifidobacterium bifidum can inhibit bone resorption: Both strains can inhibit the expression of inflammatory factors in the intestine and alleviate intestinal inflammation, thus inhibiting the overproduction of osteoclasts.

    * Bifidobacteria can protect the intestinal barrier: both strains can increase the expression of mucin and tight junction protein, thus protecting the intestinal barrier function, reducing intestinal permeability, preventing pathogens and harmful substances from entering the body, thus reducing inflammatory response.

    * Bifidobacteria can modulate the intestinal flora: B. bifidum FL228.1 increased the abundance of Lactobacillus and Colidex bacteria in the colon, while B. animalis F1-7 increased the abundance of Bifidobacterium and decreased the abundance of Desulfovibrio and Ruminalococcus.

    * :: Intestinal flora is strongly associated with bone health: The composition of the intestinal flora has been found to be strongly associated with bone health indicators such as bone density, bone volume, and number of bone trabeculae.

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